[Research progress in the regulation of pathogenesis and the transformation of chronic liver disease by short-chain fatty acids].
Zhonghua Gan Zang Bing Za Zhi
; 32(3): 268-272, 2024 Mar 20.
Article
em Zh
| MEDLINE
| ID: mdl-38584113
ABSTRACT
Short-chain fatty acids are metabolites of the intestinal flora and serve as the main energy source for intestinal epithelial cells. At the same time, as important signaling molecules, it regulate a variety of cellular inflammatory responses and homeostatic proliferation through receptor-dependent and independent pathways. Short-chain fatty acids regulate the gut-liver axis and thereby directly act on the liver, participating in the pathogenesis and transformation of various liver diseases, including alcoholic liver disease, metabolic dysfunction-related liver disease, autoimmune liver disease, liver fibrosis, and hepatocellular carcinoma. In addition, short-chain fatty acids can inhibit HBV DNA replication. This article reviews the research progress on the role of short-chain fatty acids in aspects of the pathogenesis and transformation of chronic liver diseases.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Hepatopatia Gordurosa não Alcoólica
/
Neoplasias Hepáticas
Limite:
Humans
Idioma:
Zh
Ano de publicação:
2024
Tipo de documento:
Article