Self-Assembly of Sulfate-Containing Peptides Sequesters VEGF for Inhibiting Cancer Cell Invasion.
Biomacromolecules
; 25(5): 3087-3097, 2024 May 13.
Article
em En
| MEDLINE
| ID: mdl-38584438
ABSTRACT
Heparan sulfate proteoglycans (HSPGs) play a crucial role in regulating cancer growth and migration by mediating interactions with growth factors. In this study, we developed a self-assembling peptide (S1) containing a sulfate group to simulate the contiguous sulfated regions (S-domains) in heparan sulfate for growth factor binding, aiming to sequester growth factors like VEGF. Spectral and structural studies as well as simulation studies suggested that S1 self-assembled into nanostructures similar to the heparan sulfate chains and effectively bound to VEGF. On cancer cell surfaces, S1 self-assemblies sequestered VEGF, leading to a reduction in VEGF levels in the medium, consequently inhibiting cancer cell growth, invasion, and angiogenesis. This study highlights the potential of self-assembling peptides to emulate extracellular matrix functions, offering insights for future cancer therapeutic strategies.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Peptídeos
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Fator A de Crescimento do Endotélio Vascular
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Invasividade Neoplásica
Limite:
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article