Huntington's disease: A clinical primer for acute and general physicians.
Clin Med (Lond)
; 24(2): 100200, 2024 Mar.
Article
em En
| MEDLINE
| ID: mdl-38588915
ABSTRACT
Huntington's disease (HD) usually manifests in adulthood and is characterised by progressive neurodegeneration in the brain that causes worsening involuntary movements, mental health and cognition over many years. Depression, anxiety and apathy are common. HD is autosomal dominant and affects about 1 in 8,000 people in the UK. There are currently no disease-modifying treatments and so patient care centres on multidisciplinary therapy support and medical treatments to relieve distressing symptoms. Progression of HD is usually slow, and so acute deteriorations often indicate another problem, such as intercurrent infections, constipation, urinary retention, gastro-oesophageal reflux disease or poor dentition. In this review we outline common presentations in HD patients, both acute and chronic, consider therapeutic options and discuss specific considerations in advanced HD.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Doença de Huntington
Limite:
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article