A large normative connectome for exploring the tractographic correlates of focal brain interventions.
Sci Data
; 11(1): 353, 2024 Apr 08.
Article
em En
| MEDLINE
| ID: mdl-38589407
ABSTRACT
Diffusion-weighted MRI (dMRI) is a widely used neuroimaging modality that permits the in vivo exploration of white matter connections in the human brain. Normative structural connectomics - the application of large-scale, group-derived dMRI datasets to out-of-sample cohorts - have increasingly been leveraged to study the network correlates of focal brain interventions, insults, and other regions-of-interest (ROIs). Here, we provide a normative, whole-brain connectome in MNI space that enables researchers to interrogate fiber streamlines that are likely perturbed by given ROIs, even in the absence of subject-specific dMRI data. Assembled from multi-shell dMRI data of 985 healthy Human Connectome Project subjects using generalized Q-sampling imaging and multispectral normalization techniques, this connectome comprises ~12 million unique streamlines, the largest to date. It has already been utilized in at least 18 peer-reviewed publications, most frequently in the context of neuromodulatory interventions like deep brain stimulation and focused ultrasound. Now publicly available, this connectome will constitute a useful tool for understanding the wider impact of focal brain perturbations on white matter architecture going forward.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Conectoma
/
Substância Branca
Limite:
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article