The prognostic value of preoperative peripheral blood inflammatory indicators for squamous cell carcinoma of tongue.

ABSTRACT

OBJECTIVES: A study was conducted to investigate the value of preoperative peripheral blood inflammatory indicators in the prediction of tongue squamous cell carcinoma (TSCC) prognosis. METHODS: This retrospective analysis included 210 patients who underwent radical resection for TSCC in the Department of Oral and Maxillofacial Surgery of The First Affiliated Hospital of Zhengzhou University from January 2010 to December 2017. Receiver operating characteristic curve was conducted to determine the best cut-off values of platelet/lymphocyte ratio (PLR) and neutrophil/lymphocyte ratio (NLR). The Kaplan-Meier method and Log-rank test were conducted for univariate analysis, and the Cox proportional hazard regression model was conducted for multivariate analysis. A Nomogram model was established based on the independent risk factors, which were screened by Cox regression model. RESULTS: The univariate analysis showed that PLR, NLR, tumor differentiation, and T, N, and TNM stages were TSCC's prognostic factors (P<0.05). Multivariate analysis showed that PLR and N and TNM stages were TSCC's independent risk factors (P<0.05). The C-index of the Nomogram was 0.701 (95%CI 0.651-0.752). The calibration curve shows that the predicted survival rate of the nomogram was in good agreement with the relative survival rate. CONCLUSIONS: Preoperative peripheral blood inflammatory indicators can potentially be used to predict TSCC prognosis.