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Cinnamic Acid: A Low-Toxicity Natural Bidentate Ligand for Uranium Decorporation.
Liu, Yawen; Zhao, Bin; He, Pan; Wang, Zeru; Tang, Kui; Mou, Zhiwei; Tan, Yi; Wu, Linzhen; Chen, Guangyuan; Li, Xiaoan; Zhu, Lin; Duan, Tao.
Afiliação
  • Liu Y; School of Life Sciences and Engineering, Southwest University of Science and Technology, Mianyang 629000, China.
  • Zhao B; State Key Laboratory of Environment-friendly Energy Materials, National Co-innovation Center for Nuclear Waste Disposal and Environmental Safety, Southwest University of Science and Technology, Mianyang 621010, Sichuan, China.
  • He P; NHC Key Laboratory of Nuclear Technology Medical Transformation (Mianyang Central Hospital), Mianyang 621010, China.
  • Wang Z; State Key Laboratory of Environment-friendly Energy Materials, National Co-innovation Center for Nuclear Waste Disposal and Environmental Safety, Southwest University of Science and Technology, Mianyang 621010, Sichuan, China.
  • Tang K; College of Chemistry, Key Laboratory of Radiation Physics & Technology, Ministry of Education, Sichuan University, Chengdu 610064, China.
  • Mou Z; State Key Laboratory of Environment-friendly Energy Materials, National Co-innovation Center for Nuclear Waste Disposal and Environmental Safety, Southwest University of Science and Technology, Mianyang 621010, Sichuan, China.
  • Tan Y; NHC Key Laboratory of Nuclear Technology Medical Transformation (Mianyang Central Hospital), Mianyang 621010, China.
  • Wu L; State Key Laboratory of Environment-friendly Energy Materials, National Co-innovation Center for Nuclear Waste Disposal and Environmental Safety, Southwest University of Science and Technology, Mianyang 621010, Sichuan, China.
  • Chen G; NHC Key Laboratory of Nuclear Technology Medical Transformation (Mianyang Central Hospital), Mianyang 621010, China.
  • Li X; State Key Laboratory of Environment-friendly Energy Materials, National Co-innovation Center for Nuclear Waste Disposal and Environmental Safety, Southwest University of Science and Technology, Mianyang 621010, Sichuan, China.
  • Zhu L; State Key Laboratory of Environment-friendly Energy Materials, National Co-innovation Center for Nuclear Waste Disposal and Environmental Safety, Southwest University of Science and Technology, Mianyang 621010, Sichuan, China.
  • Duan T; State Key Laboratory of Environment-friendly Energy Materials, National Co-innovation Center for Nuclear Waste Disposal and Environmental Safety, Southwest University of Science and Technology, Mianyang 621010, Sichuan, China.
Inorg Chem ; 63(16): 7464-7472, 2024 Apr 22.
Article em En | MEDLINE | ID: mdl-38598182
ABSTRACT
Uranium accumulation in the kidneys and bones following internal contamination results in severe damage, emphasizing the pressing need for the discovery of actinide decorporation agents with efficient removal of uranium and low toxicity. In this work, cinnamic acid (3-phenyl-2-propenoic acid, CD), a natural aromatic carboxylic acid, is investigated as a potential uranium decorporation ligand. CD demonstrates markedly lower cytotoxicity than that of diethylenetriaminepentaacetic acid (DTPA), an actinide decorporation agent approved by the FDA, and effectively removes approximately 44.5% of uranyl from NRK-52E cells. More importantly, the results of the prompt administration of the CD solution remove 48.2 and 27.3% of uranyl from the kidneys and femurs of mice, respectively. Assessments of serum renal function reveal the potential of CD to ameliorate uranyl-induced renal injury. Furthermore, the single crystal of CD and uranyl compound (C9H7O2)2·UO2 (denoted as UO2-CD) reveals the formation of uranyl dimers as secondary building units. Thermodynamic analysis of the solution shows that CD coordinates with uranyl to form a 21 molar ratio complex at a physiological pH of 7.4. Density functional theory (DFT) calculations further show that CD exhibits a significant 7-fold heightened affinity for uranyl binding in comparison to DTPA.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Urânio / Cinamatos Limite: Animals Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Urânio / Cinamatos Limite: Animals Idioma: En Ano de publicação: 2024 Tipo de documento: Article