Application of Natural Medicinal Plants Active Ingredients in Oral Squamous Cell Carcinoma.
Chin J Integr Med
; 30(9): 852-864, 2024 Sep.
Article
em En
| MEDLINE
| ID: mdl-38607612
ABSTRACT
Oral squamous cell carcinoma (OSCC) is the most common malignant cancer of the head and neck, with high morbidity and mortality, ranking as the sixth most common cancer in the world. The treatment of OSCC is mainly radiotherapy, chemotherapy and surgery, however, the prognosis of patients is still poor and the recurrence rate is high. This paper reviews the range of effects of natural medicinal plant active ingredients (NMPAIs) on OSCC cancer, including the types of NMPAIs, anti-cancer mechanisms, involved signaling pathways, and clinical trials. The NMPAIs include terpenoids, phenols, flavonoids, glycosides, alkaloids, coumarins, and volatile oils. These active ingredients inhibit proliferation, induce apoptosis and autophagy, inhibit migration and invasion of OSCC cells, and regulate cancer immunity to exert anti-cancer effects. The mechanism involves signaling pathways such as mitogen-activated protein kinase, phosphatidylinositol 3 kinase/protein kinase B, nuclear factor kappa B, miR-22/WNT1/ß-catenin and Nrf2/Keap1. Clinically, NMPAIs can inhibit the growth of OSCC, and the combined drug is more effective. Natural medicinal plants are promising candidates for the treatment of OSCC.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Plantas Medicinais
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Neoplasias Bucais
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Carcinoma de Células Escamosas
Limite:
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article