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Targeting GPRC5D in multiple myeloma.
Elemian, Shatha; Al Hadidi, Samer.
Afiliação
  • Elemian S; Department of Internal Medicine, Saint Michael's Medical Center, Newark, NJ, USA.
  • Al Hadidi S; Myeloma Institute, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Expert Rev Anticancer Ther ; 24(5): 229-238, 2024 May.
Article em En | MEDLINE | ID: mdl-38607646
ABSTRACT

INTRODUCTION:

The prognosis of multiple myeloma (MM) continues to improve. Recent progress in therapies, using immunomodulatory drugs (IMiDs), proteasome inhibitors (PIs), and anti-CD38 monoclonal antibodies, has greatly improved patients' outcomes. Despite these advancements, relapses still happen often, and patients can become resistant to the usual treatments. Newer treatments, such as chimeric antigen receptor (CAR) T-cell therapy and bispecific antibodies (BsAbs) targeting B-cell maturation antigen (BCMA), have resulted in excellent outcomes in patients with limited treatment options. G protein - coupled receptor, class C group 5 member D (GPRC5D) is considered a very promising target with early results from clinical trials showing high response rates in patients with relapsed or refractory multiple myeloma. AREAS COVERED This review covers the efficacy and safety of CAR-T and BsAbs targeting GPRC5D in MM, focusing on talquetamab - the inaugural FDA-approved BsAb targeting GPRC5D. Talquetamab has exhibited promising response rates alongside a distinctive side effect profile. Additionally, ongoing trials examining talquetamab in combination with agents like daratumumab and teclistamab are discussed. EXPERT OPINION We offer insights into the potential utilization of various GPRC5D-based therapies in the treatment paradigm for MM, either independently or in combination with established therapies.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptores Acoplados a Proteínas G / Mieloma Múltiplo Limite: Animals / Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptores Acoplados a Proteínas G / Mieloma Múltiplo Limite: Animals / Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article