The Impact of Local Programmatic Decisions on Outcomes in Transplant-Listed Adults With Congenital Heart Disease.
J Card Fail
; 2024 Apr 12.
Article
em En
| MEDLINE
| ID: mdl-38616008
ABSTRACT
BACKGROUND:
We investigated variables impacting waitlist times and negative waitlist outcomes in adults with congenital heart disease (ACHD) who were waiting for orthotopic heart transplant (OHT) after the 2018 allocation change.METHODS:
Adult candidates for OHT who were listed between 10/18/2018 and 12/31/2022 in the United Network for Organ Sharing database were categorized as ACHD vs non-ACHD. Waitlist time and time to upgrade for those upgraded into status 1-3 were compared by using rank-sum tests. Death/delisting for deterioration was assessed by using Fine-Gray subdistribution hazard ratios (SHRs).RESULTS:
Of 15,424 OHT candidates, 589 (3.8%) were ACHD. ACHD vs non-ACHD candidates had less urgent status at initial listing (4.2% vs 4.7% listed at status 1; 17.2% vs 23.7% listed at status 2; P < 0.001), but not final listing (5.9% vs 7.6% final status 1; 35.6% vs 36.8% final status 2; P < 0.001). ACHD vs non-ACHD candidates upgraded into status 1 (65.0 vs 30.0 days; Pâ¯=â¯0.09) and status 2 (113.0 vs 64.0 days; Pâ¯=â¯0.003) spent longer times on the waitlist. ACHD vs non-ACHD candidates spent longer times waiting for an upgrade into status 1 (51.4 vs 17.6 days; Pâ¯=â¯0.027) and status 2 (76.7 vs 34.7 days; Pâ¯=â¯0.003). Once upgraded, there was no difference between groups in waitlist time to status 1 (9.7 vs 5.5 daysâ¯=â¯0.66). ACHD vs non-ACHD candidates with a final status of 1 (20.0% vs 8.6%; SHR 2.47 [95%CIâ¯=â¯1.19-5.16]; Pâ¯=â¯0.02) and 2 (8.9% vs 2.3%; SHR 3.59 [95%CIâ¯=â¯2.18-5.91]; P < 0.001) experienced higher rates of death and deterioration.CONCLUSIONS:
ACHD candidates have longer waitlist times, have lower priority status at initial listing, wait longer for upgrades, and have higher mortality rates at the same final status as non-ACHD candidates, suggesting that they are being upgraded too late.
Texto completo:
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Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article