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Efficacy and Nuances of Precision Molecular Engineering for Hodgkin's Disease to a Gene Therapeutic Approach.
Qadir, Muhammad Imran; Ahmed, Bilal; Hussain, Nadir.
Afiliação
  • Qadir MI; Institute of Molecular Biology & Biotechnology, Bahauddin Zakariya University, Multan, Pakistan.
  • Ahmed B; University of Science And Technology of Fujairah, UAE; School of Pharmacy, Nanjing Medical University, Nanjing, Jiangsu Province, China.
  • Hussain N; Bahauddin Zakariya University Multan.
Crit Rev Immunol ; 44(5): 41-50, 2024.
Article em En | MEDLINE | ID: mdl-38618727
ABSTRACT
Gene therapy is a particularly useful treatment for nervous system genetic diseases, including those induced especially by infectious organisms and antigens, and is being utilized to treat Hodgkin's disease (HD). Due to the possible clonal relationship between both disorders, immunotherapy directed against CD20 positive cells may be a more effective treatment in patients with persistent HD and NHL. HL growth can be inhibited both in vitro and in vivo by AdsIL-13Ralpha2. High-dose treatment combined with stem cell transplantation has been effective in treating HIV-negative lymphoma that has progressed to high-risk or relapsed disease. For therapy, LMP2-specific CTL will be used. Furthermore, it is possible to view the cytotoxicity of genetically modified adenoviruses that express proteins such as p27Kip1, p21Waf1, and p16INK4A as a foundational element for (2,5)-derived ALCL genetic treatment for Hodgkin's disease.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Hodgkin / Transplante de Células-Tronco Hematopoéticas Limite: Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Hodgkin / Transplante de Células-Tronco Hematopoéticas Limite: Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article