Electrochemical Benzylic C(sp3)-H Imidation Enabled by Benzoic Acid Derived Radicals.
J Org Chem
; 89(9): 6395-6404, 2024 May 03.
Article
em En
| MEDLINE
| ID: mdl-38621116
ABSTRACT
We developed an electrochemical approach for benzylic C(sp3)-H imidation by virtue of the in situ generated oxygen-centered radicals (OCRs). The electrochemical imidation provides a complementary approach to giving distinct imide products compared with previous acyloxylation products. This protocol exhibits good site selectivity and broad substrate generality. Moreover, the utility of the OCR-mediated protocol was extended to the electrochemical oxidation of silane, and its robustness was also highlighted by the imidation of complex substrates, which would otherwise be inaccessible for previous approaches. A plausible reaction mechanism was proposed to rationalize the experimental observations.
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MEDLINE
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En
Ano de publicação:
2024
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Article