Injectable isoniazid-loaded bone cement based on hydrazone bonds achieving long-term release and decent mechanical properties.
J Mater Chem B
; 12(18): 4389-4397, 2024 May 08.
Article
em En
| MEDLINE
| ID: mdl-38623831
ABSTRACT
A robust and easily manufactured high-strength and long-term release hydrazone-based isoniazid acrylic (HIA) bone cement is reported. The mechanical strength of HIA bone cement is similar to that of normal polymethyl methacrylate (PMMA) bone cement, far surpassing that of traditional isoniazid-containing antibiotic-loaded bone cement (INH bone cement). Isoniazid is connected to the bone cement through bioorthogonal hydrazone chemistry, and it possesses release properties superior to those of INH bone cement, allowing for the sustained release of isoniazid for up to 12 weeks. In vivo and in vitro studies also indicate that HIA cement exhibits better biocompatibility than INH bone cement. The results of this study not only signify progress in the realm of antimicrobial bone cement for addressing bone tuberculosis but also enhance our capacity to create and comprehend high-performing antimicrobial bone cement.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Cimentos Ósseos
/
Hidrazonas
/
Isoniazida
Limite:
Animals
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article