Cobalt-Catalyzed Acceptorless Dehydrogenation of Primary Amines to Nitriles.
J Am Chem Soc
; 146(17): 11801-11810, 2024 May 01.
Article
em En
| MEDLINE
| ID: mdl-38626455
ABSTRACT
The direct double dehydrogenation from primary amines to nitriles without an oxidant or hydrogen acceptor is both intriguing and challenging. In this paper, we describe a non-noble metal catalyst capable of realizing such a transformation with high efficiency. A cobalt-centered N,N-bidentate complex was designed and employed as a metal-ligand cooperative dehydrogenation catalyst. Detailed kinetic studies, control experiments, and DFT calculations revealed the crucial hydride transfer, proton transfer, and hydrogen evolution processes. Finally, a tandem outer-sphere/inner-sphere mechanism was proposed for the dehydrogenation of amines to nitriles through an imine intermediate.
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MEDLINE
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En
Ano de publicação:
2024
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Article