Association of serum uric acid with functional disability in older subjects: a population-based study.
Aging Clin Exp Res
; 36(1): 96, 2024 Apr 17.
Article
em En
| MEDLINE
| ID: mdl-38630352
ABSTRACT
BACKGROUND:
The role of serum uric acid (SUA) in the development of adverse health outcomes in advanced age is still uncertain.AIMS:
The aim of the study was to assess the association of disability with SUA levels in older community-dwelling subjects.METHODS:
We assessed the association of disability with SUA in all 351 inhabitants of Tuscania (Italy) aged 75+. Functional ability was estimated using the instrumental activities of daily living (IADLs).RESULTS:
In logistic regression, increasing SUA levels were associated with disability (OR = 1.22; 95%CI = 1.01-1.48; P = .036), after adjusting. The association was independent of both gender and age (P for interaction > 0.050). SUA levels above 5.5 mg/dL best predicted disability.CONCLUSIONS:
In older subjects, SUA levels are associated with disability; the cut off level above 5.5 mg/dL might be adopted in pharmacological trials aiming at reducing the incidence and progression of disability by reducing SUA, and for identifying subjects at increased risk of disability.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Ácido Úrico
/
Atividades Cotidianas
Limite:
Aged
/
Humans
País como assunto:
Europa
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article