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Dess-Martin periodinane-mediated oxidation of the primary alcohol of cytidine into a carboxylic acid.
Serre, Alexandra R E; Jha, Vibhu; Rivault, Adèle; Eriksson, Leif A; Ribeiro Morais, Goreti; Falconer, Robert A.
Afiliação
  • Serre ARE; Institute of Cancer Therapeutics, Faculty of Life Sciences, University of Bradford, Bradford BD7 1DP, UK. r.a.falconer1@bradford.ac.uk.
  • Jha V; Department of Chemistry and Molecular Biology, University of Gothenburg, 405 30 Göteborg, Sweden.
  • Rivault A; Institute of Cancer Therapeutics, Faculty of Life Sciences, University of Bradford, Bradford BD7 1DP, UK. r.a.falconer1@bradford.ac.uk.
  • Eriksson LA; Department of Chemistry and Molecular Biology, University of Gothenburg, 405 30 Göteborg, Sweden.
  • Ribeiro Morais G; Institute of Cancer Therapeutics, Faculty of Life Sciences, University of Bradford, Bradford BD7 1DP, UK. r.a.falconer1@bradford.ac.uk.
  • Falconer RA; Institute of Cancer Therapeutics, Faculty of Life Sciences, University of Bradford, Bradford BD7 1DP, UK. r.a.falconer1@bradford.ac.uk.
Org Biomol Chem ; 22(19): 3848-3853, 2024 May 15.
Article em En | MEDLINE | ID: mdl-38635230
ABSTRACT
Herein the first example of conversion of alcohols into carboxylic acids by use of the Dess-Martin Periodinane (DMP), which is otherwise routinely employed for the conversion to aldehydes, is reported. This methodology will have significant potential utility in the synthesis of cytidine analogues and other related biologically important molecules.

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article