Your browser doesn't support javascript.
loading
Oncolytic virotherapy stimulates anti­tumor immune response and demonstrates activity in advanced sarcoma: Report of two cases.
Qiu, Yeting; Qin, Aijun; Zhao, Ronghua; Ding, Jun; Jia, William Wei-Guo; Singh, Manu; Murad, Yanal; Tan, Qian; Kichenadasse, Ganessan.
Afiliação
  • Qiu Y; Shanghai Virogin Biotech Ltd., Shanghai 200240, P.R. China.
  • Qin A; Shanghai Virogin Biotech Ltd., Shanghai 200240, P.R. China.
  • Zhao R; Shanghai Virogin Biotech Ltd., Shanghai 200240, P.R. China.
  • Ding J; Virogin Biotech Canada Ltd., Richmond, BC V6V 3A4, Canada.
  • Jia WW; China National Biotec Group (CNBG) - Virogin Biotech (Shanghai) Co., Ltd., Shanghai 200240, P.R. China.
  • Singh M; Shanghai Virogin Biotech Ltd., Shanghai 200240, P.R. China.
  • Murad Y; Virogin Biotech Canada Ltd., Richmond, BC V6V 3A4, Canada.
  • Tan Q; Shanghai Virogin Biotech Ltd., Shanghai 200240, P.R. China.
  • Kichenadasse G; Virogin Biotech Canada Ltd., Richmond, BC V6V 3A4, Canada.
Oncol Lett ; 27(6): 244, 2024 Jun.
Article em En | MEDLINE | ID: mdl-38638849
ABSTRACT
Sarcoma is derived from mesenchymal neoplasms and has numerous subtypes, accounting for 1% of all adult malignancies and 15% of childhood malignancies. The prognosis of metastatic or recurrent sarcoma remains poor. The current study presents two cases of sarcoma enrolled in a phase I dose escalation trial for solid tumor, who had previously failed all standard therapies. These patients were treated with VG161, an immune-stimulating herpes simplex virus type 1 oncolytic virus with payloads of IL-12, IL-15 and IL-15 receptor α unit, and a programmed cell death 1 (PD-1)/PD-1 ligand 1 blocking peptide. Both cases demonstrated stable disease as the best response, accompanied by a noteworthy prolongation of progression-free survival (11.8 months for chondrosarcoma and 11.9 months for soft tissue sarcoma, respectively) at a dose of 2.5×108 PFU/cycle. In addition, the treatment led to the activation of anti-cancer immunity, as evident from cytokine, lymphocyte subset and related pathway analyses of peripheral blood and/or tumor biopsy samples. These promising results suggest that VG161 monotherapy holds promise as an effective treatment for sarcoma and warrants further investigation through clinical trials. The two reported patients were part of a phase I clinical trial conducted and registered on the Australian New Zealand Clinical Trials Registry in Australia (registration no. ACTRN12620000244909; registration date, 26 February, 2020).
Palavras-chave

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article