Iridium-catalyzed asymmetric cascade dearomative allylation/acyl transfer rearrangement: access to chiral N-substituted 2-pyridones.
Chem Commun (Camb)
; 60(38): 5086-5089, 2024 May 07.
Article
em En
| MEDLINE
| ID: mdl-38639097
ABSTRACT
Iridium-catalyzed dearomative allylation/acyl transfer rearrangement has been developed using easily available 2-pyridinyl benzoates and vinyl ethylene carbonate. This protocol enabled the expedient synthesis of a variety of chiral N-substituted 2-pyridones in good to high yields with excellent enantioselectivity. It has the advantages of high atom economy, wide substrate scope, gram-scale synthesis, and versatile synthetic transformations.
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Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2024
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Article