Recent developments in the enzymatic modifications of steroid scaffolds.
Org Biomol Chem
; 22(18): 3559-3583, 2024 05 08.
Article
em En
| MEDLINE
| ID: mdl-38639195
ABSTRACT
Steroids are an important family of bioactive compounds. Steroid drugs are renowned for their multifaceted pharmacological activities and are the second-largest category in the global pharmaceutical market. Recent developments in biocatalysis and biosynthesis have led to the increased use of enzymes to enhance the selectivity, efficiency, and sustainability for diverse modifications of steroids. This review discusses the advancements achieved over the past five years in the enzymatic modifications of steroid scaffolds, focusing on enzymatic hydroxylation, reduction, dehydrogenation, cascade reactions, and other modifications for future research on the synthesis of novel steroid compounds and related drugs, and new therapeutic possibilities.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Esteroides
Limite:
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article