Nervogenic Acid Derivatives and Phenanthrenes from Liparis nervosa and Their Antimicrobial and Immunosuppressive Activities.
Chem Biodivers
; 21(7): e202400721, 2024 Jul.
Article
em En
| MEDLINE
| ID: mdl-38639576
ABSTRACT
Two new nervogenic acid derivatives liparisnervosides Q (1) and R (5), as well as five known nervogenic acid derivatives (2-4, 6, 7) and four phenanthrenes (8-11) were isolated from the whole plant of Liparis nervosa (Thunb. ex A. Murray) Lindl.. Their structures were detremined using extensive spectroscopic techniques, including 1D, 2D NMR, and HR-ESI-MS, and acid hydrolysis. Furthermore, their antimicrobial and immunosuppressive activities were evaluated. Nervosine VII (3) exhibited antimicrobial activity against Staphylococcus aureus with an MIC of 62.5â
µg/mL and inhibited the proliferation of human T cells with an IC50 value of 9.67±0.96â
µM. These findings contribute to our understanding of the potential pharmacological properties of these compounds.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Fenantrenos
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Staphylococcus aureus
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Testes de Sensibilidade Microbiana
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Proliferação de Células
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Imunossupressores
Limite:
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article