Mild exercise expedites joint clearance and slows joint degradation in a joint instability model of osteoarthritis in male rats.
Osteoarthritis Cartilage
; 32(7): 912-921, 2024 Jul.
Article
em En
| MEDLINE
| ID: mdl-38642879
ABSTRACT
OBJECTIVE:
Exercise remains a hallmark treatment for post-traumatic osteoarthritis (PTOA) and may maintain joint homeostasis in part by clearing inflammatory cytokines, cells, and particles. It remains largely unknown whether exercise-induced joint clearance can provide therapeutic relief of PTOA. In this study, we hypothesized that exercise could slow the progression of preclinical PTOA in part by enhancing knee joint clearance.DESIGN:
Surgical medial meniscal transection was used to induce PTOA in 3-month-old male Lewis rats. A sham surgery was used as a control. Mild treadmill walking was introduced 3 weeks post-surgery and maintained to 6 weeks post-surgery. Gait and isometric muscle torque were measured at the study endpoint. Near-infrared imaging tracked how exercise altered lymphatic and venous knee joint clearance during discrete time points of PTOA progression.RESULTS:
Exercise mitigated joint degradation associated with PTOA by preserving glycosaminoglycan content and reducing osteophyte volume (effect size (95% Confidence Interval (CI)); 1.74 (0.71-2.26)). PTOA increased hind step widths (0.57 (0.18-0.95) cm), but exercise corrected this gait dysfunction (0.54 (0.16-0.93) cm), potentially indicating pain relief. Venous, but not lymphatic, clearance was quicker 1-, 3-, and 6-weeks post-surgery compared to baseline. The mild treadmill walking protocol expedited lymphatic clearance rate in moderate PTOA (3.39 (0.20-6.59) hrs), suggesting exercise may play a critical role in restoring joint homeostasis.CONCLUSIONS:
We conclude that mild exercise has the potential to slow disease progression in part by expediting joint clearance in moderate PTOA.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Condicionamento Físico Animal
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Ratos Endogâmicos Lew
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Osteoartrite do Joelho
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Instabilidade Articular
Limite:
Animals
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article