Association of IL-6-572 polymorphism with sepsis: An updated meta-analysis.
Cytokine
; 179: 156597, 2024 07.
Article
em En
| MEDLINE
| ID: mdl-38643631
ABSTRACT
OBJECTIVES:
To analyze the relationship between IL and 6 572C/G polymorphism with sepsis.METHODS:
Searching 8 databases the Cochrane Library, China National Knowledge Infrastructure (CNKI), China Biology Medicine (CBM), Chongqing VIP, Embase, PubMed, WanFang Data, and Web of Science from inception to October 1, 2023. Meta-analysis was performed by using Review Manager 5.4 and STATA 15.0.RESULTS:
9 studies were included, 1 study was excluded from the previous meta-analysis, and 6 studies were added. Sensitivity analysis suggested that the results were relatively robust. The P values of Egger test indicated that no conspicuous publication bias was found.CONCLUSION:
According to the meta-analysis results of existing studies, the IL-6 572C/G GG genotype and G allele are risk factors for sepsis, this result changes the previous conclusion that the IL-6 572 polymorphism is not related to sepsis. However, the results still need to be conservatively treated due to the sample size was not large enough.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Interleucina-6
/
Sepse
/
Predisposição Genética para Doença
/
Polimorfismo de Nucleotídeo Único
Limite:
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article