Harnessing beta cell regeneration biology for diabetes therapy.
Trends Endocrinol Metab
; 2024 Apr 20.
Article
em En
| MEDLINE
| ID: mdl-38644094
ABSTRACT
The pandemic scale of diabetes mellitus is alarming, its complications remain devastating, and current treatments still pose a major burden on those affected and on the healthcare system as a whole. As the disease emanates from the destruction or dysfunction of insulin-producing pancreatic ß-cells, a real cure requires their restoration and protection. An attractive strategy is to regenerate ß-cells directly within the pancreas; however, while several approaches for ß-cell regeneration have been proposed in the past, clinical translation has proven challenging. This review scrutinizes recent findings in ß-cell regeneration and discusses their potential clinical implementation. Hereby, we aim to delineate a path for innovative, targeted therapies to help shift from 'caring for' to 'curing' diabetes.
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MEDLINE
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En
Ano de publicação:
2024
Tipo de documento:
Article