Astrocytes at the intersection of ageing, obesity, and neurodegeneration.
Clin Sci (Lond)
; 138(8): 515-536, 2024 Apr 24.
Article
em En
| MEDLINE
| ID: mdl-38652065
ABSTRACT
Once considered passive cells of the central nervous system (CNS), glia are now known to actively maintain the CNS parenchyma; in recent years, the evidence for glial functions in CNS physiology and pathophysiology has only grown. Astrocytes, a heterogeneous group of glial cells, play key roles in regulating the metabolic and inflammatory landscape of the CNS and have emerged as potential therapeutic targets for a variety of disorders. This review will outline astrocyte functions in the CNS in healthy ageing, obesity, and neurodegeneration, with a focus on the inflammatory responses and mitochondrial function, and will address therapeutic outlooks.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Envelhecimento
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Astrócitos
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Doenças Neurodegenerativas
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Obesidade
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article