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Genomic landscape of diploid and aneuploid microsatellite stable early onset colorectal cancer.
Zhou, Yumei; Chen, Xianfeng; Chen, Jun; Kendrick, Conner D; Ramanathan, Ramesh K; Graham, Rondell P; Kossick, Kimberlee F; Boardman, Lisa A; Barrett, Michael T.
Afiliação
  • Zhou Y; Department of Research, Mayo Clinic in Arizona, Scottsdale, AZ, USA.
  • Chen X; Division of Computational Biology, Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, 55905, USA.
  • Chen J; Division of Computational Biology, Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, 55905, USA.
  • Kendrick CD; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, 55905, USA.
  • Ramanathan RK; Mayo Clinic Cancer Center, Phoenix, AZ, 85054, USA.
  • Graham RP; Ironwood Cancer and Research Center, Scottsdale, AZ, 85260, USA.
  • Kossick KF; Anatomic Pathology, Mayo Clinic, Rochester, MN, 55905, USA.
  • Boardman LA; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, 55905, USA.
  • Barrett MT; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, 55905, USA.
Sci Rep ; 14(1): 9368, 2024 04 23.
Article em En | MEDLINE | ID: mdl-38654044
ABSTRACT
Although colorectal cancer (CRC) remains the second leading cause of cancer-related death in the United States, the overall incidence and mortality from the disease have declined in recent decades. In contrast, there has been a steady increase in the incidence of CRC in individuals under 50 years of age. Hereditary syndromes contribute disproportionately to early onset CRC (EOCRC). These include microsatellite instability high (MSI+) tumors arising in patients with Lynch Syndrome. However, most EOCRCs are not associated with familial syndromes or MSI+ genotypes. Comprehensive genomic profiling has provided the basis of improved more personalized treatments for older CRC patients. However, less is known about the basis of sporadic EOCRC. To define the genomic landscape of EOCRC we used DNA content flow sorting to isolate diploid and aneuploid tumor fractions from 21 non-hereditary cases. We then generated whole exome mutational profiles for each case and whole genome copy number, telomere length, and EGFR immunohistochemistry (IHC) analyses on subsets of samples. These results discriminate the molecular features of diploid and aneuploid EOCRC and provide a basis for larger population-based studies and the development of effective strategies to monitor and treat this emerging disease.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Diploide / Instabilidade de Microssatélites / Aneuploidia Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Diploide / Instabilidade de Microssatélites / Aneuploidia Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2024 Tipo de documento: Article