Daphmacrimines A-K, Daphniphyllum alkaloids from Daphniphyllum macropodum Miq.
Phytochemistry
; 223: 114106, 2024 Jul.
Article
em En
| MEDLINE
| ID: mdl-38657885
ABSTRACT
Daphmacrimines A-K (1-11) were isolated from the leaves and stems of Daphniphyllum macropodum Miq. Their structures and stereochemistries were determined by extensive techniques, including HRESIMS, NMR, ECD, IR, and single-crystal X-ray crystallography. Daphmacrimines A-D (1-4) are unprecedented Daphniphyllum alkaloids with a 2-oxazolidinone ring. Daphmacrimine I (9) contains a nitrile group, which is relatively rare in naturally occurring alkaloids. The abilities of daphmacrimines A-D and daphmacrimines G-K to enhance lysosomal biogenesis were evaluated through LysoTracker Red staining. Daphmacrimine K (11) can induce lysosomal biogenesis and promote autophagic flux.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Alcaloides
/
Daphniphyllum
Limite:
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article