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Psilocybin therapy and anorexia nervosa: a narrative review of safety considerations for researchers and clinicians.
Downey, Amanda E; Chaphekar, Anita V; Woolley, Joshua; Raymond-Flesch, Marissa.
Afiliação
  • Downey AE; Department of Pediatrics, University of California, San Francisco, CA, USA. amanda.downey@ucsf.edu.
  • Chaphekar AV; Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, CA, USA. amanda.downey@ucsf.edu.
  • Woolley J; Department of Pediatrics, University of California, San Francisco, CA, USA.
  • Raymond-Flesch M; Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, CA, USA.
J Eat Disord ; 12(1): 49, 2024 Apr 24.
Article em En | MEDLINE | ID: mdl-38659049
ABSTRACT

BACKGROUND:

Clinical trials using psilocybin therapy to treat anorexia nervosa (AN) are currently underway. The safety and tolerability of psilocybin is of utmost importance in individuals with AN who may present unique medical vulnerabilities. The purpose of this review is to describe how the common physiologic adverse effects of psilocybin may impact medical complications experienced by individuals with AN in clinical trials of psilocybin therapy. MAIN BODY The physiologic underpinnings of common adverse effects following psilocybin administration are described, including tachycardia, hypertension, electrocardiogram changes, nausea, headache, and lightheadedness. These anticipated physiologic changes are described in relation to the common medical correlates seen in individuals with AN. Risk mitigation strategies for each adverse effect are proposed.

CONCLUSION:

Early evidence suggests that psilocybin therapy is well-tolerated in individuals with AN. Understanding the unique medical complications of AN, and how they may be impacted by common physiologic adverse effects of psilocybin administration, leads to tailored risk mitigation strategies to enhance safety and tolerability of this novel intervention.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article