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PPAR-γ regulates the polarization of M2 macrophages to improve the microenvironment for autologous fat grafting.
Zhang, Ya-An; Li, Fang-Wei; Dong, Yun-Xian; Xie, Wen-Jie; Wang, Hai-Bin.
Afiliação
  • Zhang YA; Department of Plastic and Reconstructive Surgery, Guangdong Second Provincial General Hospital, Guangzhou, China.
  • Li FW; Department of Plastic and Reconstructive Surgery, Guangdong Second Provincial General Hospital, Guangzhou, China.
  • Dong YX; Department of Plastic and Reconstructive Surgery, Guangdong Second Provincial General Hospital, Guangzhou, China.
  • Xie WJ; Department of Plastic and Reconstructive Surgery, Guangdong Second Provincial General Hospital, Guangzhou, China.
  • Wang HB; Department of Plastic and Reconstructive Surgery, Guangdong Second Provincial General Hospital, Guangzhou, China.
FASEB J ; 38(8): e23613, 2024 Apr 30.
Article em En | MEDLINE | ID: mdl-38661048
ABSTRACT
The unpredictable survival rate of autologous fat grafting (AFG) seriously affects its clinical application. Improving the survival rate of AFG has become an unresolved issue in plastic surgery. Peroxisome proliferator-activated receptor-γ (PPAR-γ) regulates the adipogenic differentiation of adipocytes, but the functional mechanism in AFG remains unclear. In this study, we established an animal model of AFG and demonstrated the superior therapeutic effect of PPAR-γ regulation in the process of AFG. From day 3 after fat grafting, the PPAR-γ agonist rosiglitazone group consistently showed better adipose integrity, fewer oil cysts, and fibrosis. Massive macrophage infiltration was observed after 7 days. At the same time, M2 macrophages begin to appear. At day 14, M2 macrophages gradually became the dominant cell population, which suppressed inflammation and promoted revascularization and fat regeneration. In addition, transcriptome sequencing showed that the differentially expressed genes in the Rosiglitazone group were associated with the pathways of adipose regeneration, differentiation, and angiogenesis; these results provide new ideas for clinical treatment.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transplante Autólogo / Tecido Adiposo / PPAR gama / Rosiglitazona / Macrófagos Limite: Animals Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transplante Autólogo / Tecido Adiposo / PPAR gama / Rosiglitazona / Macrófagos Limite: Animals Idioma: En Ano de publicação: 2024 Tipo de documento: Article