Evaluation of anorectal function using real-time tissue elastography before and after preoperative chemoradiotherapy.
Int J Colorectal Dis
; 39(1): 56, 2024 Apr 25.
Article
em En
| MEDLINE
| ID: mdl-38662090
ABSTRACT
PURPOSE:
This study aimed to clarify the relationship between changes in elasticity and anorectal function before and after chemoradiotherapy.METHODS:
This is a single-center prospective cohort study (Department of Surgical Oncology, The University of Tokyo). We established a technique to quantify internal anal sphincter hardness as elasticity using transanal ultrasonography with real-time tissue elastography. Twenty-seven patients with post-chemoradiotherapy rectal cancer during 2019-2022 were included. Real-time tissue elastography with transanal ultrasonography was performed before and after chemoradiotherapy to measure internal anal sphincter hardness as "elasticity" (hardest (0) to softest (255); decreased elasticity indicated sclerotic changes). The relationship between the increase or decrease in elasticity pre- and post-chemoradiotherapy and the maximum resting pressure, maximum squeeze pressure, and Wexner score were the outcome measures.RESULTS:
A decrease in elasticity was observed in 16/27 (59.3%) patients after chemoradiotherapy. Patients with and without elasticity decrease after chemoradiotherapy comprised the internal anal sphincter sclerosis and non-sclerosis groups, respectively. The maximum resting pressure post-chemoradiotherapy was significantly high in the internal anal sphincter sclerosis group (63.0 mmHg vs. 47.0 mmHg), and a majority had a worsening Wexner score (60.0% vs. 18.2%) compared with that of the non-sclerosis group. Decreasing elasticity (internal anal sphincter sclerosis) correlated with a higher maximum resting pressure (r = 0.36); no correlation was observed between the degree of elasticity change and maximum squeeze pressure.CONCLUSION:
Internal anal sphincter sclerosis due to chemoradiotherapy may correlate to anorectal dysfunction.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Canal Anal
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Neoplasias Retais
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Técnicas de Imagem por Elasticidade
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Quimiorradioterapia
Limite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article