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Subsequent malignant neoplasms after primary hematological malignancy in adult patients.
Rönkkö, Rosa M; Nevala, Aapeli O; Pitkäniemi, Janne M; Wartiovaara-Kautto, Ulla M; Malila, Nea K.
Afiliação
  • Rönkkö RM; Finnish Cancer Registry, Cancer Society of Finland, Helsinki, Finland.
  • Nevala AO; Department of Internal Medicine, Helsinki University Hospital Physical Medicine and Rehabilitation, Helsinki, Finland.
  • Pitkäniemi JM; Department of Hematology, University of Helsinki, Helsinki, Finland.
  • Wartiovaara-Kautto UM; Finnish Cancer Registry, Cancer Society of Finland, Helsinki, Finland.
  • Malila NK; Department of Mathematics and Statistics, University of Helsinki, Helsinki, Finland.
Int J Cancer ; 155(6): 1007-1013, 2024 Sep 15.
Article em En | MEDLINE | ID: mdl-38664865
ABSTRACT
Patients with primary hematological malignancy (HM) are at an elevated risk of subsequent malignant neoplasms (SMNs), which is a common concern after treatment of primary cancer. We identified 45,533 patients aged ≥20 years and diagnosed with primary HM in Finland from 1992 to 2019 from the Finnish Cancer Registry and estimated standardized incidence ratios (SIR) and excess absolute risks per 1000 person-years (EAR) for SMNs. A total of 6076 SMNs were found (4604 solid and 1472 hematological SMNs). The SIRs were higher for hematological SMNs (SIR 4.9, 95% confidence interval [CI] 4.7-5.2) compared to solid SMNs (SIR 1.5, 95% CI 1.4-1.5). The SIRs for hematological SMNs were highest in the young HM patients aged 20-39 years (SIR 9.2, 95% CI 6.8-12.2 in males and SIR 10.5, 95% CI 7.2-14.7 in females) and decreased by age of first primary HM. However, EARs for hematological SMNs were highest in the older patients, aged 60-79 years at their first primary HM (EAR 5.7/1000 and 4.7/1000 in male and female patients, respectively). In conclusion, the incidence of both hematological and solid SMNs were increased in hematological cancer patients. The relative risk (SIR) was highest among younger HM patients with hematological SMNs. The absolute second cancer burden reflected by high EAR arises from solid malignancies in older patients. Our results accentuate the need for vigilance in the surveillance of HM patients.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sistema de Registros / Segunda Neoplasia Primária / Neoplasias Hematológicas Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País como assunto: Europa Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sistema de Registros / Segunda Neoplasia Primária / Neoplasias Hematológicas Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País como assunto: Europa Idioma: En Ano de publicação: 2024 Tipo de documento: Article