Gold-catalyzed benzannulations of 2-alkenylindoles with alkynes: a protecting-group-free regioselective approach to carbazoles.
Chem Commun (Camb)
; 60(40): 5326-5329, 2024 May 14.
Article
em En
| MEDLINE
| ID: mdl-38666614
ABSTRACT
A gold(I)-catalyzed protecting-group-free benzannulation approach to functionalized NH-carbazoles was accomplished via the hydroarylation of alkynes with 2-alkenylindoles. A broad spectrum of terminal and internal alkynes and 2-alkenylindoles successfully participated in this annulation reaction. The protocol efficiently enabled the formation of substituted NH-carbazoles with moderate to specific regioselectivities. The synthetic utility of this protocol was demonstrated by a variety of post-functionalizations.
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MEDLINE
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En
Ano de publicação:
2024
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Article