Hai-Honghua medicinal liquor is a reliable remedy for fracture by promotion of osteogenic differentiation via activation of PI3K/Akt pathway.

Qian, Die; Zhang, Qing; He, Cheng-Xun; Guo, Juan; Huang, Xiao-Ting; Zhao, Jun; Zhang, Hong; Xu, Chi; Peng, Wei

Qian, Die; Zhang, Qing; He, Cheng-Xun; Guo, Juan; Huang, Xiao-Ting; Zhao, Jun; Zhang, Hong; Xu, Chi; Peng, Wei.

Afiliação

Qian D; State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China.
Zhang Q; State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China.
He CX; State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China.
Guo J; State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China.
Huang XT; Department of Orthopedics, Longquan Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, 610017, China.
Zhao J; Department of Orthopedics, Longquan Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, 610017, China.
Zhang H; State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Xu C; Department of Orthopedics, Longquan Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, 610017, China. Electronic address: xuchizy@163.com.
Peng W; State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China. Electronic address: pengwei@cdutcm.edu.cn.

J Ethnopharmacol ; 330: 118234, 2024 Aug 10.

Article em En | MEDLINE | ID: mdl-38670404

Assuntos

Diferenciação Celular; Medicamentos de Ervas Chinesas; Osteoblastos; Osteogênese; Proteínas Proto-Oncogênicas c-akt; Ratos Sprague-Dawley; Animais; Medicamentos de Ervas Chinesas/farmacologia; Proteínas Proto-Oncogênicas c-akt/metabolismo; Masculino; Osteogênese/efeitos dos fármacos; Humanos; Camundongos; Diferenciação Celular/efeitos dos fármacos; Feminino; Pessoa de Meia-Idade; Adulto; Ratos; Osteoblastos/efeitos dos fármacos; Transdução de Sinais/efeitos dos fármacos; Consolidação da Fratura/efeitos dos fármacos; Fosfatidilinositol 3-Quinases/metabolismo; Fraturas Ósseas/tratamento farmacológico; Idoso; Adulto Jovem; Modelos Animais de Doenças

Palavras-chave

Fractures; Hai-honghua medicinal liquor; MC3T3-E1 cells; Osteoblast differentiation; PI3K/Akt signaling pathway

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Osteoblastos / Osteogênese / Medicamentos de Ervas Chinesas / Diferenciação Celular / Ratos Sprague-Dawley / Proteínas Proto-Oncogênicas c-akt Limite: Adult / Aged / Animals / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2024 Tipo de documento: Article

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