Juvenile xanthogranuloma manifesting with LCH-associated neurodegenerative disease-like radiological findings.
Pediatr Blood Cancer
; 71(7): e31043, 2024 Jul.
Article
em En
| MEDLINE
| ID: mdl-38679849
ABSTRACT
Here, we describe two patients with juvenile xanthogranuloma (JXG) manifesting with Langerhans cell histiocytosis (LCH)-associated neurodegenerative disease (ND)-like radiological findings. One patient showed typical radiological abnormalities at onset, which worsened with progressing central nervous system symptoms 7 years after LCH-oriented chemotherapy. Another showed spontaneous regression of clinical symptoms, with a transient radiological change 1 year after salvage chemotherapy for recurrence of JXG. These data regarding JXG-associated ND will facilitate future investigation of the disease, as well as development of therapeutic interventions.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Histiocitose de Células de Langerhans
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Xantogranuloma Juvenil
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Doenças Neurodegenerativas
Limite:
Child
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Humans
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Infant
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Male
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article