Can the HB-EGF/EGFR pathway restore injured neurons?
FEBS J
; 291(10): 2094-2097, 2024 May.
Article
em En
| MEDLINE
| ID: mdl-38680125
ABSTRACT
Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a transmembrane protein that, when cleaved by metalloproteases through a process called ectodomain shedding, binds to the EGF receptor (EGFR), activating downstream signaling. The HB-EGF/EGFR pathway is crucial in development and is involved in numerous pathophysiological processes. In this issue of The FEBS Journal, Sireci et al. reveal a previously unexplored function of the HB-EGF/EGFR pathway in promoting neuronal progenitor proliferation and sensory neuron regeneration in the zebrafish olfactory epithelium in response to injury.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Peixe-Zebra
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Transdução de Sinais
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Receptores ErbB
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Fator de Crescimento Semelhante a EGF de Ligação à Heparina
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article