Effects of Obstructive Sleep Apnea on Airway Immunity and Susceptibility to Respiratory Infections.
Sleep Med Clin
; 19(2): 219-228, 2024 Jun.
Article
em En
| MEDLINE
| ID: mdl-38692747
ABSTRACT
Obstructive sleep apnea is a prevalent sleep disorder characterized by recurrent episodes of partial or complete upper airway collapse during sleep, leading to disrupted breathing patterns and intermittent hypoxia. OSA results in systemic inflammation but also directly affects the upper and lower airways leading to upregulation of inflammatory pathways and alterations of the local microbiome. These changes result in increased susceptibility to respiratory infections such as influenza, COVID-19, and bacterial pneumonia. This relationship is more complex and bidirectional in individuals with chronic lung disease such as chronic obstructive lung disease, interstitial lung disease and bronchiectasis.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Infecções Respiratórias
/
Apneia Obstrutiva do Sono
Limite:
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article