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Understanding the genomic heterogeneity of North African Imazighen: from broad to microgeographical perspectives.
Vilà-Valls, Laura; Abdeli, Amine; Lucas-Sánchez, Marcel; Bekada, Asmahan; Calafell, Francesc; Benhassine, Traki; Comas, David.
Afiliação
  • Vilà-Valls L; Departament de Medicina i Ciències de la Vida, Institut de Biologia Evolutiva (CSIC-UPF), Universitat Pompeu Fabra, Barcelona, Spain.
  • Abdeli A; Laboratoire de Biologie Cellulaire et Moléculaire, Faculté Des Sciences Biologiques, Université des Sciences et de la Technologie Houari Boumediene, Alger, Algeria.
  • Lucas-Sánchez M; Departament de Medicina i Ciències de la Vida, Institut de Biologia Evolutiva (CSIC-UPF), Universitat Pompeu Fabra, Barcelona, Spain.
  • Bekada A; Département de Biotechnologie, Faculté des Sciences de la Nature et de la Vie, Université Oran 1 (Ahmad Ben Bella), Oran, Algeria.
  • Calafell F; Departament de Medicina i Ciències de la Vida, Institut de Biologia Evolutiva (CSIC-UPF), Universitat Pompeu Fabra, Barcelona, Spain.
  • Benhassine T; Laboratoire de Biologie Cellulaire et Moléculaire, Faculté Des Sciences Biologiques, Université des Sciences et de la Technologie Houari Boumediene, Alger, Algeria.
  • Comas D; Departament de Medicina i Ciències de la Vida, Institut de Biologia Evolutiva (CSIC-UPF), Universitat Pompeu Fabra, Barcelona, Spain. david.comas@upf.edu.
Sci Rep ; 14(1): 9979, 2024 05 01.
Article em En | MEDLINE | ID: mdl-38693301
ABSTRACT
The strategic location of North Africa has led to cultural and demographic shifts, shaping its genetic structure. Historical migrations brought different genetic components that are evident in present-day North African genomes, along with autochthonous components. The Imazighen (plural of Amazigh) are believed to be the descendants of autochthonous North Africans and speak various Amazigh languages, which belong to the Afro-Asiatic language family. However, the arrival of different human groups, especially during the Arab conquest, caused cultural and linguistic changes in local populations, increasing their heterogeneity. We aim to characterize the genetic structure of the region, using the largest Amazigh dataset to date and other reference samples. Our findings indicate microgeographical genetic heterogeneity among Amazigh populations, modeled by various admixture waves and different effective population sizes. A first admixture wave is detected group-wide around the twelfth century, whereas a second wave appears in some Amazigh groups around the nineteenth century. These events involved populations with higher genetic ancestry from south of the Sahara compared to the current North Africans. A plausible explanation would be the historical trans-Saharan slave trade, which lasted from the Roman times to the nineteenth century. Furthermore, our investigation shows that assortative mating in North Africa has been rare.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Heterogeneidade Genética / Migração Humana / Genética Populacional / População do Oriente Médio e Norte da África Limite: Humans País como assunto: Africa Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Heterogeneidade Genética / Migração Humana / Genética Populacional / População do Oriente Médio e Norte da África Limite: Humans País como assunto: Africa Idioma: En Ano de publicação: 2024 Tipo de documento: Article