Sarcocinerenolides A, an open-loop decarbonizing cembranolide, and sarcocinerenolides B-I, eight polyoxygenated cembranolides with anti-thrombotic activity from the South China Sea soft coral Sarcophyton cinereum.
Phytochemistry
; 223: 114109, 2024 Jul.
Article
em En
| MEDLINE
| ID: mdl-38697239
ABSTRACT
A previously undescribed open-loop decarbonizing cembranolide, sarcocinerenolide A, and eight undescribed cembranolides, sarcocinerenolides B-I, characterized by poly-membered oxygen ring fragments were isolated from the soft coral Sarcophyton cinereum collected from the South China Sea. The structures and absolute configurations of these previously undescribed compounds were precisely determined by analysis of NMR data, DP4+ and ECD spectra. The bioactivities of the compounds were evaluated using zebrafish models and sarcocinerenolides C and H exhibited anti-thrombotic activity.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Antozoários
/
Diterpenos
Limite:
Animals
País como assunto:
Asia
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article