Stereoselective Synthesis of Polysubstituted Dihydropyrroles via 1,5-Addition and N-1,4-Addition Cascade.

Zhang, Jing-Ming; Wang, Yu-Chao; Chen, Liang; Ma, Chao; He, Zhi-Tao

Zhang, Jing-Ming; Wang, Yu-Chao; Chen, Liang; Ma, Chao; He, Zhi-Tao.

Afiliação

Zhang JM; School of Chemistry and Materials Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, 310024, Hangzhou, China.
Wang YC; State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, 200032, Shanghai, China.
Chen L; State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, 200032, Shanghai, China.
Ma C; School of Chemistry and Materials Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, 310024, Hangzhou, China.
He ZT; State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, 200032, Shanghai, China.

Chemistry ; 30(38): e202401350, 2024 Jul 05.

Article em En | MEDLINE | ID: mdl-38700514

ABSTRACT

ABSTRACT

An unprecedented 1,5-addition/N-1,4-addition cascade reaction is established via palladium hydride catalysis. A variety of polysubstituted dihydropyrrole skeletons are constructed in high yield and with exclusively >20 1 diastereoselectivity. An enantioselective protocol of this design is also developed to provide a novel access to enantioenriched dihydropyrroles.

Palavras-chave

1,5-addition; N-1,4-addition; enantioselective; palladium hydride; stereoselective

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article

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