Synthesis, Characterization, and Cytotoxicity Evaluation of Novel Water-Soluble Cationic Platinum(II) Organometallic Complexes with Phenanthroline and Imidazolic Ligands.

Ali, Asjad; Stefàno, Erika; De Castro, Federica; Ciccarella, Giuseppe; Rovito, Gianluca; Marsigliante, Santo; Muscella, Antonella; Benedetti, Michele; Fanizzi, Francesco Paolo

Ali, Asjad; Stefàno, Erika; De Castro, Federica; Ciccarella, Giuseppe; Rovito, Gianluca; Marsigliante, Santo; Muscella, Antonella; Benedetti, Michele; Fanizzi, Francesco Paolo.

Afiliação

Ali A; Department of Biological and Environmental Sciences and Technologies (DiSTeBA), University of Salento, Via Monteroni, I-73100, Lecce, Italy.
Stefàno E; Department of Biological and Environmental Sciences and Technologies (DiSTeBA), University of Salento, Via Monteroni, I-73100, Lecce, Italy.
De Castro F; Department of Biological and Environmental Sciences and Technologies (DiSTeBA), University of Salento, Via Monteroni, I-73100, Lecce, Italy.
Ciccarella G; Department of Biological and Environmental Sciences and Technologies (DiSTeBA), University of Salento, Via Monteroni, I-73100, Lecce, Italy.
Rovito G; Department of Biological and Environmental Sciences and Technologies (DiSTeBA), University of Salento, Via Monteroni, I-73100, Lecce, Italy.
Marsigliante S; Department of Biological and Environmental Sciences and Technologies (DiSTeBA), University of Salento, Via Monteroni, I-73100, Lecce, Italy.
Muscella A; Department of Biological and Environmental Sciences and Technologies (DiSTeBA), University of Salento, Via Monteroni, I-73100, Lecce, Italy.
Benedetti M; Department of Biological and Environmental Sciences and Technologies (DiSTeBA), University of Salento, Via Monteroni, I-73100, Lecce, Italy.
Fanizzi FP; Department of Biological and Environmental Sciences and Technologies (DiSTeBA), University of Salento, Via Monteroni, I-73100, Lecce, Italy.

Chemistry ; 30(38): e202401064, 2024 Jul 05.

Article em En | MEDLINE | ID: mdl-38703115

Assuntos

Antineoplásicos; Imidazóis; Fenantrolinas; Solubilidade; Água; Humanos; Fenantrolinas/química; Fenantrolinas/farmacologia; Antineoplásicos/farmacologia; Antineoplásicos/química; Antineoplásicos/síntese química; Imidazóis/química; Imidazóis/farmacologia; Ligantes; Água/química; Linhagem Celular Tumoral; Complexos de Coordenação/química; Complexos de Coordenação/farmacologia; Complexos de Coordenação/síntese química; Cisplatino/farmacologia; Platina/química; Cátions/química; Compostos Organoplatínicos/química; Compostos Organoplatínicos/farmacologia; Compostos Organoplatínicos/síntese química; Células HeLa; Ensaios de Seleção de Medicamentos Antitumorais

Palavras-chave

anticancer drug; benzimidazole ligand; imidazole ligand; monofunctional complexes; platinum complex

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fenantrolinas / Solubilidade / Água / Imidazóis / Antineoplásicos Limite: Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article

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