Sevoflurane causes neurotoxicity and cognitive impairment by regulating Hippo signaling pathway-mediated ferroptosis via upregulating PRKCD.

Lv, Tingmin; Jia, Feiyu; Wang, Guanhua; Li, Shujia; Wan, Tingting; Qiu, Wenrui; Tang, Zhenyu; Chen, Hanwen

Lv, Tingmin; Jia, Feiyu; Wang, Guanhua; Li, Shujia; Wan, Tingting; Qiu, Wenrui; Tang, Zhenyu; Chen, Hanwen.

Afiliação

Lv T; Department of Anesthesiology, Shunde Hospital of Southern Medical University (The First People's Hospital of Shunde), No. 1 Jiazi Road, Lunjiao Street, Shunde District, Foshan City, Guangdong Province 528308, PR China.
Jia F; Department of Anesthesiology, Shunde Hospital of Southern Medical University (The First People's Hospital of Shunde), No. 1 Jiazi Road, Lunjiao Street, Shunde District, Foshan City, Guangdong Province 528308, PR China.
Wang G; Department of Anesthesiology, Shunde Hospital of Southern Medical University (The First People's Hospital of Shunde), No. 1 Jiazi Road, Lunjiao Street, Shunde District, Foshan City, Guangdong Province 528308, PR China.
Li S; Department of Anesthesiology, Shunde Hospital of Southern Medical University (The First People's Hospital of Shunde), No. 1 Jiazi Road, Lunjiao Street, Shunde District, Foshan City, Guangdong Province 528308, PR China.
Wan T; Department of Anesthesiology, Shunde Hospital of Southern Medical University (The First People's Hospital of Shunde), No. 1 Jiazi Road, Lunjiao Street, Shunde District, Foshan City, Guangdong Province 528308, PR China.
Qiu W; Department of Anesthesiology, Shunde Hospital of Southern Medical University (The First People's Hospital of Shunde), No. 1 Jiazi Road, Lunjiao Street, Shunde District, Foshan City, Guangdong Province 528308, PR China.
Tang Z; Department of Anesthesiology, Shunde Hospital of Southern Medical University (The First People's Hospital of Shunde), No. 1 Jiazi Road, Lunjiao Street, Shunde District, Foshan City, Guangdong Province 528308, PR China.
Chen H; Department of Anesthesiology, Shunde Hospital of Southern Medical University (The First People's Hospital of Shunde), No. 1 Jiazi Road, Lunjiao Street, Shunde District, Foshan City, Guangdong Province 528308, PR China. Electronic address: chenhanwen0175@163.com.

Exp Neurol ; 377: 114804, 2024 Jul.

Article em En | MEDLINE | ID: mdl-38704083

Assuntos

Disfunção Cognitiva; Ferroptose; Via de Sinalização Hippo; Hipocampo; Camundongos Knockout; Proteína Quinase C-delta; Proteínas Serina-Treonina Quinases; Sevoflurano; Transdução de Sinais; Regulação para Cima; Animais; Sevoflurano/toxicidade; Disfunção Cognitiva/induzido quimicamente; Disfunção Cognitiva/metabolismo; Disfunção Cognitiva/patologia; Disfunção Cognitiva/genética; Camundongos; Proteínas Serina-Treonina Quinases/metabolismo; Proteínas Serina-Treonina Quinases/genética; Transdução de Sinais/efeitos dos fármacos; Hipocampo/efeitos dos fármacos; Hipocampo/metabolismo; Hipocampo/patologia; Regulação para Cima/efeitos dos fármacos; Proteína Quinase C-delta/metabolismo; Proteína Quinase C-delta/genética; Ferroptose/efeitos dos fármacos; Ferroptose/fisiologia; Camundongos Endogâmicos C57BL; Masculino; Neurônios/efeitos dos fármacos; Neurônios/metabolismo; Neurônios/patologia; Anestésicos Inalatórios/toxicidade; Síndromes Neurotóxicas/patologia; Síndromes Neurotóxicas/metabolismo

Palavras-chave

Cognitive impairment; Ferroptosis; Hippo pathway; Neurotoxicity; PRKCD; Sevoflurane

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Regulação para Cima / Proteínas Serina-Treonina Quinases / Camundongos Knockout / Proteína Quinase C-delta / Disfunção Cognitiva / Sevoflurano / Ferroptose / Via de Sinalização Hippo / Hipocampo Limite: Animals Idioma: En Ano de publicação: 2024 Tipo de documento: Article

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