Recent Advances in Genomic Studies of Gestational Duration and Preterm Birth.
Clin Perinatol
; 51(2): 313-329, 2024 Jun.
Article
em En
| MEDLINE
| ID: mdl-38705643
ABSTRACT
Preterm birth (PTB) is the leading cause of infant mortality and morbidity. For several decades, extensive epidemiologic and genetic studies have highlighted the significant contribution of maternal and offspring genetic factors to PTB. This review discusses the challenges inherent in conventional genomic analyses of PTB and underscores the importance of adopting nonconventional approaches, such as analyzing the mother-child pair as a single analytical unit, to disentangle the intertwined maternal and fetal genetic influences. We elaborate on studies investigating PTB phenotypes through 3 levels of genetic analyses single-variant, multi-variant, and genome-wide variants.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Idade Gestacional
/
Nascimento Prematuro
/
Estudo de Associação Genômica Ampla
Limite:
Female
/
Humans
/
Newborn
/
Pregnancy
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article