Lipids, apolipoproteins and gestational diabetes mellitus: a Mendelian randomization study.
BMC Pregnancy Childbirth
; 24(1): 347, 2024 May 06.
Article
em En
| MEDLINE
| ID: mdl-38711000
ABSTRACT
BACKGROUND:
This study investigates the causal relationship between lipid traits and GDM in an effort to better understand the aetiology of GDM.METHODS:
Employing a two-sample Mendelian Randomization (MR) framework, we used Single Nucleotide Polymorphisms (SNPs) as instrumental variables to examine the impact of lipids and apolipoproteins on GDM. The research comprised univariable and multivariable MR analyses, with a prime focus on individual and combined effects of lipid-related traits. Statistical techniques included the fixed-effect inverse variance weighted (IVW) method and supplementary methods such as MR-Egger for comprehensive assessment.RESULTS:
Our findings revealed the following significant associations apoA-I and HDL cholesterol were inversely correlated with GDM risk, while triglycerides showed a positive correlation. In multivariable analysis, apoA-I consistently exhibited a strong causal link with GDM, even after adjusting for other lipids and Body Mass Index (BMI).CONCLUSION:
The study demonstrates a significant causal relationship between apoA-I and GDM risk.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Triglicerídeos
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Diabetes Gestacional
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Apolipoproteína A-I
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Polimorfismo de Nucleotídeo Único
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Análise da Randomização Mendeliana
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HDL-Colesterol
Limite:
Female
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Humans
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Pregnancy
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article