Mitochondria-targeted fluorescent probe for simultaneously imaging viscosity and sulfite in inflammation models.
Analyst
; 149(12): 3356-3362, 2024 Jun 10.
Article
em En
| MEDLINE
| ID: mdl-38712511
ABSTRACT
Many diseases in the human body are related to the overexpression of viscosity and sulfur dioxide. Therefore, it is essential to develop rapid and sensitive fluorescent probes to detect viscosity and sulfur dioxide. In the present work, we developed a dual-response fluorescent probe (ES) for efficient detection of viscosity and sulfur dioxide while targeting mitochondria well. The probe generates intramolecular charge transfer by pushing and pulling the electron-electron system, and the ICT effect is destroyed and the fluorescence quenched upon reaction with sulfite. The rotation of the molecule is inhibited in the high-viscosity system, producing a bright red light. In addition, the probe has good biocompatibility and can be used to detect sulfite in cells, zebrafish and mice, as well as upregulation of viscosity in LPS-induced inflammation models. We expect that the dual response fluorescent probe ES will be able to detect viscosity and sulfite efficiently, providing an effective means of detecting viscosity and sulfite-related diseases.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Sulfitos
/
Peixe-Zebra
/
Corantes Fluorescentes
/
Inflamação
/
Mitocôndrias
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article