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Micelle-based fluorogenic sensing of trypsin: a sensitive method in pancreatic disease diagnosis.
Song, Hyebin; Choi, Haemin; Kim, Young-Sun; Lee, Seoung Ho.
Afiliação
  • Song H; Department of Chemistry, Daegu University, Gyeongsan 38453, Republic of Korea. slee@daegu.ac.kr.
  • Choi H; Department of Chemistry, Daegu University, Gyeongsan 38453, Republic of Korea. slee@daegu.ac.kr.
  • Kim YS; Department of Horticultural Science, College of Natural and Life Sciences, Daegu University, Gyeongsan 38453, Republic of Korea.
  • Lee SH; Department of Chemistry, Daegu University, Gyeongsan 38453, Republic of Korea. slee@daegu.ac.kr.
Org Biomol Chem ; 22(21): 4243-4248, 2024 05 29.
Article em En | MEDLINE | ID: mdl-38712975
ABSTRACT
Protamine-mediated micellar aggregates, featuring an AIE-based fluorescent sensor, facilitate efficient detection of trypsin activity. This method enables the detection of trypsin at exceptionally low concentrations (0.01-0.1 µg mL-1) in urine, demonstrating its potential for early clinical diagnosis of trypsin-related pancreatic diseases.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pancreatopatias / Tripsina / Corantes Fluorescentes / Micelas Limite: Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pancreatopatias / Tripsina / Corantes Fluorescentes / Micelas Limite: Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article