Micelle-based fluorogenic sensing of trypsin: a sensitive method in pancreatic disease diagnosis.
Org Biomol Chem
; 22(21): 4243-4248, 2024 05 29.
Article
em En
| MEDLINE
| ID: mdl-38712975
ABSTRACT
Protamine-mediated micellar aggregates, featuring an AIE-based fluorescent sensor, facilitate efficient detection of trypsin activity. This method enables the detection of trypsin at exceptionally low concentrations (0.01-0.1 µg mL-1) in urine, demonstrating its potential for early clinical diagnosis of trypsin-related pancreatic diseases.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pancreatopatias
/
Tripsina
/
Corantes Fluorescentes
/
Micelas
Limite:
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article