New Insights into IGF-1 Signaling in the Heart.

Lee, Wang-Soo; Abel, E Dale; Kim, Jaetaek

Lee, Wang-Soo; Abel, E Dale; Kim, Jaetaek.

Afiliação

Lee WS; Division of Cardiology, Department of Internal Medicine, College of Medicine, Chung-Ang University, Seoul, Republic of Korea.
Abel ED; Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States.
Kim J; Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, Chung-Ang University, Seoul, Republic of Korea.

Physiology (Bethesda) ; 39(5): 0, 2024 09 01.

Article em En | MEDLINE | ID: mdl-38713091

ABSTRACT

ABSTRACT

Insulin-like growth factor-1 (IGF-1) signaling has multiple physiological roles in cellular growth, metabolism, and aging. Myocardial hypertrophy, cell death, senescence, fibrosis, and electrical remodeling are hallmarks of various heart diseases and contribute to the progression of heart failure. This review highlights the critical role of IGF-1 and its cognate receptor in cardiac hypertrophy, aging, and remodeling.

Assuntos

Fator de Crescimento Insulin-Like I; Transdução de Sinais; Humanos; Fator de Crescimento Insulin-Like I/metabolismo; Animais; Transdução de Sinais/fisiologia; Receptor IGF Tipo 1/metabolismo; Miocárdio/metabolismo; Envelhecimento/metabolismo; Envelhecimento/fisiologia; Coração/fisiologia; Cardiomegalia/metabolismo; Cardiomegalia/fisiopatologia

Palavras-chave

IGF-1; cardiac aging; electrical remodeling; fibrosis; receptor

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fator de Crescimento Insulin-Like I / Transdução de Sinais Limite: Animals / Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article

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