Piperazate-Guided Isolation of Caveamides A and B, Cyclohexenylalanine-Containing Nonribosomal Peptides from a Cave Actinomycete.
Org Lett
; 26(19): 4127-4131, 2024 May 17.
Article
em En
| MEDLINE
| ID: mdl-38718303
ABSTRACT
Hybrid genome-mining/15N-NMR was used to target compounds containing piperazate (Piz) residues, leading to the discovery of caveamides A (1) and B (2) from Streptomyces sp. strain BE230, isolated from New Rankin Cave (Missouri). Caveamides are highly dynamic molecules containing an unprecedented ß-ketoamide polyketide fragment, two Piz residues, and a new N-methyl-cyclohexenylalanine residue. Caveamide B (2) exhibited nanomolar cytotoxicity against several cancer cell lines and nanomolar antimicrobial activity against MRSA and E. coli.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Streptomyces
/
Escherichia coli
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Staphylococcus aureus Resistente à Meticilina
Limite:
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article