Biomimetic design of platelet-rich plasma controlled release bacterial cellulose/hydroxyapatite composite hydrogel for bone tissue engineering.
Int J Biol Macromol
; 269(Pt 2): 132124, 2024 Jun.
Article
em En
| MEDLINE
| ID: mdl-38723802
ABSTRACT
Bacterial cellulose (BC) hydrogel is renowned in the field of tissue engineering for its high biocompatibility, excellent mechanical strength, and eco-friendliness. Herein, we present a biomimetic mineralization method for preparing BC/hydroxyapatite (HAP) composite hydrogel scaffolds with different mineralization time and ion concentration of the mineralized solution. Spherical HAP reinforcement enhanced bone mineralization, thereby imparting increased bioactivity to BC matrix materials. Subsequently, platelet-rich plasma (PRP) was introduced into the scaffold. The PRP-loaded hydrogel enhanced the release of growth factors, which promoted cell adhesion, growth, and bone healing. After 3 weeks of MC3T3-E1 cell-induced osteogenesis, PRP positively affected cell differentiation in BC/HAP@PRP scaffolds. Overall, these scaffolds exhibited excellent biocompatibility, mineralized nodule formation, and controlled release in vitro, demonstrating great potential for application in bone tissue repair.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Osteogênese
/
Celulose
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Durapatita
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Hidrogéis
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Engenharia Tecidual
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Plasma Rico em Plaquetas
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Alicerces Teciduais
Limite:
Animals
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article