Behavioral Analysis of NMDAR Function in Rodents: Tests of Long-Term Spatial Memory.
Methods Mol Biol
; 2799: 107-138, 2024.
Article
em En
| MEDLINE
| ID: mdl-38727905
ABSTRACT
NMDAR-dependent forms of synaptic plasticity in brain regions like the hippocampus are widely believed to provide the neural substrate for long-term associative memory formation. However, the experimental data are equivocal at best and may suggest a more nuanced role for NMDARs and synaptic plasticity in memory. Much of the experimental data available comes from studies in genetically modified mice in which NMDAR subunits have been deleted or mutated in order to disrupt NMDAR function. Behavioral assessment of long-term memory in these mice has involved tests like the Morris watermaze and the radial arm maze. Here we describe these behavioral tests and some of the different testing protocols that can be used to assess memory performance. We discuss the importance of distinguishing selective effects on learning and memory processes from nonspecific effects on sensorimotor or motivational aspects of performance.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Receptores de N-Metil-D-Aspartato
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Aprendizagem em Labirinto
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Memória de Longo Prazo
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Memória Espacial
Limite:
Animals
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article