The efficacy and safety of leucine-enriched essential amino acids in knee osteoarthritis patients: A randomized controlled trial.
Medicine (Baltimore)
; 103(19): e38168, 2024 May 10.
Article
em En
| MEDLINE
| ID: mdl-38728455
ABSTRACT
BACKGROUND:
Supplementation with leucine-enriched essential amino acids (LEAAs) has shown efficacy in the recovery of muscle injury and activation of muscle synthesis. Muscle function in knee osteoarthritis is a crucial factor for managing pain and preserving ambulatory function. However, the efficacy and safety of LEAAs supplementation in patients with knee osteoarthritis have not been evaluated.METHODS:
In this prospective analysis, we evaluated the efficacy and safety of supplementation with 12 g of LEAAs daily for 8 weeks in knee-symptomatic osteoarthritis patients. For assessing the efficacy, clinical pain, calf circumference, and disability were assessed using questionnaires (visual analog scale, Knee Society Score, and 36-item short form survey [SF-36]), laboratory analyses (total protein and albumin), and radiologic study (dual-energy X-ray absorptiometry [DEXA]) for muscle and bone density. To evaluate safety, generalized or localized protein allergic reactions, complete blood count, liver and kidney function, and serum glucose were measured.RESULTS:
Sixty-five participants, categorized into the experimental (nâ =â 32) and control (nâ =â 33) groups, were included in this 8-week trial from March 2022 to July 2022. A significantly higher efficacy was observed in the experimental group than in the control group, as indicated by muscle density in the DEXA scan (Pâ =â .001) and SF-36 (Pâ <â .001). The safety evaluation revealed no related generalized or local protein allergy. Hematological findings, serum glucose, and kidney and liver toxicity were not significantly different between the groups.CONCLUSION:
Supplementation with leucine-enriched proteins is safe and efficacious in the improvement of muscle density and quality of life.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Suplementos Nutricionais
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Osteoartrite do Joelho
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Aminoácidos Essenciais
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Leucina
Limite:
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article