Novel biomimetic macromolecules system for highly efficient lubrication, ROS scavenging and osteoarthritis treatment.
Colloids Surf B Biointerfaces
; 239: 113956, 2024 Jul.
Article
em En
| MEDLINE
| ID: mdl-38733647
ABSTRACT
The early stages of osteoarthritis (OA) in the joints are typically characterized by two key factors the dysfunction of articular cartilage lubrication and inflammation resulting from the excessive production of reactive oxygen species (ROS). Synthetic injectable macromolecular materials present great potential for preventing the progression of early OA. In this study, to mimic the excellent lubricity of brush-like aggregates found in natural synovial fluid, we develop a novel macromolecular biolubricant (CS-PS-DA) by integrating adhesion and hydration groups onto backbone of natural biomacromolecules. CS-PS-DA exhibits a strong affinity for cartilage surfaces, enabling the formation of a stable lubrication layer at the sliding interface of degraded cartilages to restore joint lubrication performance. In vitro results from ROS scavenging and anti-inflammatory experiments indicate the great advantage of CS-PS-DA to decrease the levels of proinflammatory cytokines by inhibiting ROS overproduction. Finally, in vivo rats OA model demonstrates that intra-cavitary injection of CS-PS-DA could effectively resist cartilage wear and mitigated inflammation in the joints. This novel biolubricant provides a new and timely strategy for the treatment of OA.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Osteoartrite
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Espécies Reativas de Oxigênio
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Ratos Sprague-Dawley
Limite:
Animals
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article