Mixing energy drinks and alcohol during adolescence impairs brain function: A study of rat hippocampal plasticity.
Neuropharmacology
; 254: 109993, 2024 Aug 15.
Article
em En
| MEDLINE
| ID: mdl-38735368
ABSTRACT
In the last decades, the consumption of energy drinks has risen dramatically, especially among young people, adolescents and athletes, driven by the constant search for ergogenic effects, such as the increase in physical and cognitive performance. In parallel, mixed consumption of energy drinks and ethanol, under a binge drinking modality, under a binge drinking modality, has similarly grown among adolescents. However, little is known whether the combined consumption of these drinks, during adolescence, may have long-term effects on central function, raising the question of the risks of this habit on brain maturation. Our study was designed to evaluate, by behavioral, electrophysiological and molecular approaches, the long-term effects on hippocampal plasticity of ethanol (EtOH), energy drinks (EDs), or alcohol mixed with energy drinks (AMED) in a rat model of binge-like drinking adolescent administration. The results show that AMED binge-like administration produces adaptive hippocampal changes at the molecular level, associated with electrophysiological and behavioral alterations, which develop during the adolescence and are still detectable in adult animals. Overall, the study indicates that binge-like drinking AMED adolescent exposure represents a habit that may affect permanently hippocampal plasticity.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Etanol
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Bebidas Energéticas
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Consumo Excessivo de Bebidas Alcoólicas
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Hipocampo
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Plasticidade Neuronal
Limite:
Animals
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article